POST YOUR JOB ONLINE
Free ezine/digital edition sign up
Jobs   News   Features   Video    Products   Magazine      Advertise  
Research
Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes


Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

FEATURED SUPPLIERS

The Shredquarters partners with Physical Company to underpin expansion plans
Functional training gym, The Shredquarters, has moved into franchising, partnering with Physical Company to support its rapid growth. [more...]

Red Light Rising teams up with ITRM Clinic to supply red light therapy for injured athletes
Red light therapy equipment supplier, Red Light Rising, has partnered with Aidan Robinson of ITRM Clinic in the UK [more...]
COMPANY PROFILES
Wexer

Our mission at Wexer is to make world-class exercise accessible to everyone by harnessing the power [more...]
+ More profiles  
CATALOGUE GALLERY
 
+ More catalogues  

VIDEO GALLERY

MyZone Group Ltd - A new Zone is here
A new zone is here for your club, for your members and for you. Find out more...
+ More videos  

DIRECTORY
+ More directory  
DIARY

 

27-28 Nov 2020

National Fitness Awards 2020

Athena, Leicester, United Kingdom
01-02 Dec 2020

MIPIM Asia Summit

Grand Hyatt Hotel, Hong Kong SAR
+ More diary  
 
ABOUT LEISURE MEDIA
LEISURE MEDIA MAGAZINES
LEISURE MEDIA HANDBOOKS
LEISURE MEDIA WEBSITES
LEISURE MEDIA PRODUCT SEARCH
 
HCM
LEISURE OPPORTUNITIES
HEALTH CLUB HANDBOOK
PRINT SUBSCRIPTIONS
FREE DIGITAL SUBSCRIPTIONS
ADVERTISE . CONTACT US

Leisure Media, Portmill House, Portmill Lane,
Hitchin, Hertfordshire SG5 1DJ Tel: +44 (0)1462 431385

©Cybertrek 2020
Jobs   News   Products   Magazine
Research
Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes


Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

LATEST NEWS
'Rebel' uk gym owner Nick Whitcombe becoming global advocate for fitness
Nick Whitcombe, the independent gym owner who refused to shut his gym during the October tier 3 restrictions, is becoming a fitness industry campaigner of international renown.
The fitness industry can drive the UK’s economic recovery from the pandemic, says Huw Edwards
This year's UK government Spending Review, announced in Parliament by chancellor Rishi Sunak on 25 November, offers the physical activity sector opportunities to "transform communities", according to industry body, ukactive.
100k people to get free gym sessions as fitness industry strengthens its position as an essential service
Up to 100k people will benefit from the free gym and physical activity sessions, thanks to a partnership between ukactive, NHS England and Improvement (NHSE/I), Sport England and the National Academy for Social Prescribing.
UK fitness sector facing fight to keep group exercise open in tier 3 areas
To the relief of the sector, the UK government confirmed yesterday (23 November) that gyms, health clubs and leisure centres will be allowed to open under all three tiers of the new COVID-19 alert system when lockdown ends on 2 December.
Parliamentary debate: it's 'unthinkable' gyms could be forced to close during future lockdowns, say MPs, but minister is non-committal
Closing gyms and leisure facilities during any possible future lockdown would be "unthinkable", according to Catherine McKinnell, MP for Newcastle upon Tyne North.
Gyms in England to reopen when lockdown ends – and remain open, even in Tier 3 areas. Group ex singled out for restrictions
Gyms, health clubs and leisure centres will be able to open their doors when the current lockdown measures in England come to an end on 2 December.
Good news for gyms in analysis of NHS Track and Trace data
Gyms are right near the bottom of the list in terms of places people have visited before a positive COVID-19 test, according to UK government statistics.
Independent assessment to measure COVID-19 risk in gyms across Europe
A new, Europe-wide initiative will look to chart the level of risk of COVID-19 infection at gyms, health clubs and leisure centres across the continent.
Parliamentary debate will happen on Monday 23 November, as UK gyms are threatened with January lockdown
UK Parliament will debate COVID-19 restrictions on gyms and leisure centres on Monday 23 November, it has been confirmed.
Government's £1bn scheme to decarbonise public sector 'a huge opportunity' for leisure
The government has launched its £1bn Public Sector Decarbonisation Scheme (PSDS), providing grant funding for energy efficiency measures across the public sector.
3d Leisure introduces mental health first aiders and launches live fitness service
Leisure management company 3d Leisure is introducing two new services across its corporate division, in response to the continued uncertainties relating to the ongoing COVID-19 pandemic.
Blame obesity for high level of COVID deaths, says former chief medical officer
Thousands of COVID-related deaths could be prevented if successive governments had tackled the country's obesity crisis in time, according to Dame Sally Davies.
+ More news   
 
FEATURED SUPPLIERS

The Shredquarters partners with Physical Company to underpin expansion plans
Functional training gym, The Shredquarters, has moved into franchising, partnering with Physical Company to support its rapid growth. [more...]

Red Light Rising teams up with ITRM Clinic to supply red light therapy for injured athletes
Red light therapy equipment supplier, Red Light Rising, has partnered with Aidan Robinson of ITRM Clinic in the UK [more...]
COMPANY PROFILES
Wexer

Our mission at Wexer is to make world-class exercise accessible to everyone by harnessing the power [more...]
+ More profiles  
CATALOGUE GALLERY
+ More catalogues  

VIDEO GALLERY

MyZone Group Ltd - A new Zone is here
A new zone is here for your club, for your members and for you. Find out more...
+ More videos  

DIRECTORY
+ More directory  
DIARY

 

27-28 Nov 2020

National Fitness Awards 2020

Athena, Leicester, United Kingdom
01-02 Dec 2020

MIPIM Asia Summit

Grand Hyatt Hotel, Hong Kong SAR
+ More diary  
 


ADVERTISE . CONTACT US

Leisure Media, Portmill House, Portmill Lane,
Hitchin, Hertfordshire SG5 1DJ Tel: +44 (0)1462 431385

©Cybertrek 2020

ABOUT LEISURE MEDIA
LEISURE MEDIA MAGAZINES
LEISURE MEDIA HANDBOOKS
LEISURE MEDIA WEBSITES
LEISURE MEDIA PRODUCT SEARCH
PRINT SUBSCRIPTIONS
FREE DIGITAL SUBSCRIPTIONS