From the onset of middle-age, the brains of obese individuals display differences in white matter similar to those in lean individuals 10 years their senior, according to new research led by the University of Cambridge, UK*.

White matter is the tissue that connects areas of the brain and allows for information to be communicated between regions.

Our brains shrink with age, but scientists are recognising that obesity – already linked to conditions such as diabetes, cancer and heart disease – may also affect the onset and progression of brain ageing; however, direct studies to support this link are lacking.

Impact of obesity
In a cross-sectional study – one that looks at data from individuals at one point in time – researchers investigated the impact of obesity on brain structure across the adult lifespan to find out whether obesity was associated with brain changes characteristic of ageing. The team studied data from 473 individuals between the ages of 20 and 87, recruited by the Cambridge Centre for Ageing and Neuroscience. The results were published in the journal Neurobiology of Aging.

The researchers divided the data into two categories: lean and overweight. They found striking differences in the volume of white matter in the brains of overweight individuals compared with those of their leaner counterparts. Overweight individuals had a widespread reduction in white matter compared to lean people.

The team then calculated how white matter volume related to age across the two groups. They discovered that an overweight person at, say, 50 years old had a comparable white matter volume to a lean person aged 60 years, implying a difference in brain age of 10 years.

Most vulnerable time
Strikingly, differences in white matter were only observed from middle-age onwards, suggesting our brains may be particularly vulnerable during this period of ageing.
“As our brains age, they naturally shrink in size, but it isn’t clear why people who are overweight have a greater reduction in the amount of white matter,” says first author Dr Lisa Ronan from the Department of Psychiatry at the University of Cambridge. “We can only speculate on whether obesity might in some way cause these changes or whether obesity is a consequence of brain changes.”

Senior author professor Paul Fletcher from the Department of Psychiatry adds: “We’re living in an ageing population, with increasing levels of obesity, so it’s essential that we establish how these two factors might interact, since the consequences for health are potentially serious.

“The fact that we only saw these differences from middle-age onwards raises the possibility that we may be particularly vulnerable at this age. It will also be important to find out whether these changes could be reversible with weight loss, which may well be the case.”

Despite the clear differences in the volume of white matter between lean and overweight individuals, the researchers found no connection between being overweight or obese and an individual’s cognitive abilities, as measured using a standard test similar to an IQ test.

* Ronan, L et al. Obesity associated with increased brain-age from mid-life. Neurobiology of Aging. July 2016