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Study: exercise stalls cancer growth by changing T cells in the immune system
13 Nov 2020 . BY Tom Walker
evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells
Photo: Shutterstock.com/Liderina
Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.

Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the Department of Cell and Molecular Biology, Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells.

Johnson is the author of a study – published in the journal eLife – which makes the connection.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health as well as help us design and improve treatments against cancer,” Johnson said.

To examine how exercise influenced cancer growth, the researchers observed two groups of mice – one which exercised regularly and a group which remained inactive.

In order to understand how exercise influenced cancer growth, the researchers isolated T cells, blood and tissue samples after training sessions and measured levels of common metabolites that are produced in muscle and excreted into plasma at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells isolated from an exercised animal showed an altered metabolism compared to T cells from resting animals.

During the study, it became clear that cancer growth slowed and mortality decreased in the trained animals, when compared with the untrained.

Helene Rundqvist, the study’s first author and senior researcher at the Department of Laboratory Medicine, Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results may contribute to a deeper understanding of how our lifestyle impacts our immune system and inform the development of new immunotherapies against cancer.”

• To download and read the entire study, click here for the eLife journal.
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PRODUCT NEWS
Study: exercise stalls cancer growth by changing T cells in the immune system
13 Nov 2020 . BY Tom Walker
evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells
Photo: Shutterstock.com/Liderina
Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.

Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the Department of Cell and Molecular Biology, Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells.

Johnson is the author of a study – published in the journal eLife – which makes the connection.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health as well as help us design and improve treatments against cancer,” Johnson said.

To examine how exercise influenced cancer growth, the researchers observed two groups of mice – one which exercised regularly and a group which remained inactive.

In order to understand how exercise influenced cancer growth, the researchers isolated T cells, blood and tissue samples after training sessions and measured levels of common metabolites that are produced in muscle and excreted into plasma at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells isolated from an exercised animal showed an altered metabolism compared to T cells from resting animals.

During the study, it became clear that cancer growth slowed and mortality decreased in the trained animals, when compared with the untrained.

Helene Rundqvist, the study’s first author and senior researcher at the Department of Laboratory Medicine, Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results may contribute to a deeper understanding of how our lifestyle impacts our immune system and inform the development of new immunotherapies against cancer.”

• To download and read the entire study, click here for the eLife journal.
PRODUCT NEWS
Copper clothing can keep staff and members safe
Snap Fitness franchisee, Kunal Patel, is kitting out all staff – from personal trainers to cleaners – with copper-infused masks and gloves from medtech company, Copper Clothing.
Playfinder launches Bookteq to increase revenue for independent facility operators
Playfinder has launched Bookteq, a booking system aimed at increasing revenue for operators of independent physical activity venues.
Cryotherapy specialists, L&R Kältetechnik, launch new artofcryo.com division
L&R Kältetechnik has launched a new division, named artofcryo.com, after 30 years’ experience with -110 °C electrical solutions.
Funxtion collaborates with global experts on white paper exploring digital in the future of fitness
In collaboration with ukactive, FunXtion has driven a global discussion with some of the world’s leading fitness operators and influencers, exploring how digitalisation will influence the delivery of fitness services and products moving forwards.
Primal Strength bolsters Scottish expansion with Matrix Fitness distribution win
Matrix Fitness has announced an exclusive partnership with Primal Strength to target an increased strategic focus on the Scottish market.
Anytime Fitness partners with Gympass across UK and Ireland
Anytime Fitness, the UK’s leading 24/7 high-spec gym operator, has partnered with Gympass to give its corporate members access to over 170 clubs across UK and Ireland.
Not all fitness content is equal
With the launch of 22 SERIES, a pioneering, new cardio line powered by iFit® – the world’s leading on-demand fitness streaming platform – Freemotion Fitness aims to change the way we think about – and deliver – fitness content to truly engage members.
Active IQ launches End-point Assessor qualification
Active IQ has launched its Level 3 Award in Understanding the Development and Delivery of End-point Assessment to meet the increasing demands for skilled assessors in this emerging area.
Dr Paul Bedford announces Retention Convention will go virtual for 2020
Global retention expert, Dr Paul Bedford, will host his sixth annual Retention Convention virtually, bringing together global speakers to form a documentary-style event around turning customers into communities.
The Shredquarters partners with Physical Company to underpin expansion plans
Functional training gym, The Shredquarters, has moved into franchising, partnering with Physical Company to support its rapid growth.
Converting members in January has never been so simple with Volution’s new Lead Generation tool
Volution – the leading data solutions specialist for the fitness industry – has launched a Lead Generation tool that enables operators to harness the power of mobile technology and cloud-based infrastructure to streamline sales.
Club Industry and Sibec unveil Future of Fitness virtual event to help reinvent the fitness industry
The COVID-19 pandemic has temporarily halted opportunities to gather in-person to discuss vital topics relating to the fitness industry’s future.
+ More products   
 
COMPANY PROFILES
Bungee Super Fly

[more...]
+ More profiles  
CATALOGUE GALLERY
+ More catalogues  

VIDEO GALLERY

MyZone Group Ltd - A new Zone is here
A new zone is here for your club, for your members and for you. Find out more...
+ More videos  

DIRECTORY
+ More directory  
DIARY

 

27-28 Nov 2020

National Fitness Awards 2020

Athena, Leicester, United Kingdom
01-02 Dec 2020

MIPIM Asia Summit

Grand Hyatt Hotel, Hong Kong SAR
+ More diary  
 


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Hitchin, Hertfordshire SG5 1DJ Tel: +44 (0)1462 431385

©Cybertrek 2020

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